Hepatitis B Vaccine Centre in Hyderabad, India
At PACE Hospitals, discover peace of mind through our comprehensive Hepatitis vaccination services, including the crucial Hepatitis B vaccine. Rely on our seasoned specialists to fortify your health journey with confidence. Schedule your vaccination appointment today and embrace a brighter, healthier future alongside us!
Protect Your Health:
Book Your Hepatitis Vaccine!
People residing in Hyderabad who are seeking 'Hepatitis Vaccine near me' can schedule an appointment online at PACE Hospitals by completing the form above titled 'Request an Appointment for Hepatitis vaccine' or can call our appointment desk at 04048486868.
These are some additional things to keep in mind when visiting center for Vaccination:
- Know your vaccination schedule: You can find the recommended vaccine dose schedule by age, here 👉Hepatitis Vaccine Schedule.
- Please remember to bring your previous vaccination records. This will assist our doctor in determining which Hepatitis vaccine or any other vaccinations you have already received.
Hepatitis vaccination is the immunization of individuals against a group of deadly viral diseases that affect the liver, primarily swelling it and progressing to liver cirrhosis and, ultimately, cancer.
There are commonly 5 main hepatitis viruses, designated as types A, B, C, D and E which cause Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D and Hepatitis E respectively. These diseases are of greatest concern due to the increased burden of illness and death they bring globally, especially Hepatitis B.
Types of hepatitis
Five human viruses have been well described till date, including hepatitis A (HAV), B (HBV), C (HCV), D (HDV) and E (HEV). Each type of viral hepatitis causes a similar pathology, with acute inflammation of the liver.
Types A and E are classically associated with acute and sometimes severe hepatitis, which is invariably self-limited but occasionally fatal. Hepatitis B causes acute hepatitis in adults, and 5% of patients become chronic carriers, while 95% of patients infected in the neonatal period are chronically infected. Hepatitis C rarely causes acute hepatitis, but up to 85% of patients become chronic carriers.
Both viruses cause chronic liver inflammation or hepatitis, cirrhosis, and hepatocellular carcinoma (liver cancer). The prevalence and mechanisms of transmissions are included in the table below.
| Virus | Prevalence worldwide | The main mechanism of transmission. |
|---|---|---|
| Hepatitis A virus | Accounting for up to 25% of clinical hepatitis in the developed world. | Contaminated food |
| Hepatitis B virus | Up to 50 crores worldwide | Exposure to Hepatitis B virus at birth (vertical transmission), sexual transmission and contaminated blood transfusions |
| Hepatitis C virus | Over 17 crores worldwide | Commonly through sharing contaminated needles. The vertical transmission rate from infected mother to child is less than 3%. |
| Hepatitis D virus | Seen only in Hepatitis B patients. At least 5% of Hepatitis B carriers worldwide are infected with Hepatitis D. | Through permucosally (through mucous contact), percutaneously (through skin contact), or sexually |
| Hepatitis E virus | Endemic in India, Asia, the Middle East, and parts of Latin America. | Contaminated food |
Vaccination being one of the most efficacious measures to reduce the global incidence of hepatitis, is also an economically attractive option when compared with other healthcare interventions. The vaccination status of each hepatitis diseases includes:
| Disease | Vaccination status |
|---|---|
| Hepatitis A | Safe and effective vaccines are feasible to prevent HAV. |
| Hepatitis B | Safe and effective vaccines are available to prevent HAV. |
| Hepatitis C | There is no vaccine for HCV. |
| Hepatitis D | Hepatitis B vaccine provided protection from HDV infection. |
| Hepatitis E | Safe and effective vaccines are developed but are not widely available. |
Efficacy of hepatitis B vaccine
Several hundred crore doses of hepatitis B vaccine have been delivered worldwide fighting hepatitis with an excellent record of safety and efficacy. These details depicted an effective stance against hepatitis B disease.
- Following a full course of vaccination (3 doses of vaccine given at 0, 1, and 6 months), the protection rates to antibodies against hepatitis B surface antigen (HBsAg) is close to 100% in children and almost 95% in healthy young adults.
- In the elderly, obese, heavy smokers, or immunocompromised, including those infected with human immunodeficiency virus (HIV), suboptimal responses to vaccinations are discovered. Immunodeficient patients, such as those undergoing hemodialysis or immunosuppressant therapy, require higher Hepatitis vaccine doses to achieve an adequate immune response.
- Third-generation recombinant triple-antigen vaccines have been reported to be effective for the revaccination of people who had an inadequate response to current vaccines or in immunosuppressed Hepatitis B patients after liver transplantation.
Hepatitis Vaccine Shot Recipients (Who needs)
When hepatitis B vaccine became available in industrialized countries, strategies for HBV control were initially focused on the immunization of high-risk groups. Rapid protection from hepatitis is necessary for the following risk populations:
- Health care workers who are in danger of being exposed to Hepatitis B virus (such as nurses working in intensive care units, dialysis staff, blood bank staff, laboratory staff dealing with blood samples and surgeons and other doctors at high-risk)
- Care takers attending a patient inflicted with Hepatitis B
- Susceptible sexual partner of an acute hepatitis B patient
- Homosexual men
- Drug users
- People with multiple sex partners
- Patients who are HIV-seropositive
- Patients with chronic liver disease (CLD) and
- Patients with chronic kidney disease (CKD)
Types of hepatitis b vaccine
Four major serotypes, and nine minor subtypes, have been serologically identified at the hepatitis B surface antigen level. To counter the advent of hepatitis, and enhance its prevention, various types of hepatitis vaccines have been invented. The journey of hepatitis is seen below:
- 1st generation hepatitis B vaccine (plasma-derived): The United States and France collaborated in the early 1980s to produce the first hepatitis B vaccinations. These are plasma-derived vaccines that are prepared by the extraction of minuscule particles of hepatitis B surface antigen. Despite obtaining formidable success, there had been growing concerns in Europe and North America due to the potential contamination of vaccines.
- 2nd generation hepatitis B vaccine (HBV DNA vaccine, expressed in yeast): Through the modern technology, second-generation vaccines have been developed. The hepatitis B surface antigen was genetically modified within yeast cells, infused with hepatitis B virus surface gene. Both host factors and vaccine-related factors could impact on the vaccine’s efficacy.
- 3rd generation hepatitis B vaccine (HBV-infected mammalian cells): In the third-generation vaccines, HBV-infected mammalian cells are used, which included hamster ovary (CHO) cells among others.
Are vaccination combinations necessary?
In the year 2000, the European Union approved a hexagonal vaccine, (six-in-one vaccine), for the primary immunization of infants within the first year of their life, which protects against the infections of polio, tetanus, diphtheria, pertussis, hepatitis B, and infections caused by H. influenza type B.
Vaccination combinations were started as a result of extensive research which demonstrated that each of these above said vaccination do retain their immunogenic properties despite combining them, also research demonstrated their safety and tolerability.
Similarly, combination vaccinations of hepatitis A and B have been devised which facilitate immunogenicity to vulnerable populations, which include tourists from prevalent areas and military personnel. It was proven that the safety and efficacy of the combined vaccinations can be comparable to those of monovalent hepatitis A and B vaccines administration.
Hepatitis B vaccine schedule
Since India falls in the Asia-Pacific region, which contains nearly 75% of all global HBV carriers, the World Health Organisation (WHO) issued a complete hepatitis B vaccine schedule, which consists of three doses of vaccine administration after the birth-dose with a 4-week interval within each dose.
- As the name suggests, the birth dose is given within 24 hours of the birth of the infant.
- An interval of at least four weeks is maintained after the birth dose to administer the first, second, and third doses. The table can help us better understand it.
| 1st HB Vaccine dose | 2nd HB Vaccine dose | 3rd HB Vaccine dose | 4th HB Vaccine dose |
|---|---|---|---|
| Within 24 hours of birth | 6th week | 10th week | 14th week |
Hepatitis B vaccine schedule for adults
Prevaccination screening in the general population has not been found to be cost-effective in India. In adults, the dose is 20 μg. Booster is not needed in immunocompetent adults.
Booster immunization & its necessity in Hepatitis B vaccine
Booster vaccination: This is an additional vaccination dose which is administered after a previous vaccination. The booster dose in vaccination is necessary either for the maintenance or for the extension of the protective immune response.
Studies have demonstrated that vaccine-induced antibody persists over periods of at least 10–15 years. Follow-up of those who had been vaccinated have shown that the antibody concentrations usually decline over time. Nevertheless, clinically significant breakthrough infections are rare in successfully vaccinated people.
Evidence demonstrates that successfully vaccinated individuals who have lost their antibodies over time usually show a rapid and enhanced response of the individual’s immune system to the Hepatitis B virus when an additional dose of vaccine is given several years after the primary course of vaccination or when exposed to the Hepatitis B virus.
Data collected during the first 10–20 years of vaccination in countries of both high and low endemicity demonstrated that the routine administration of booster dose may not be necessary in the case of immunocompetent children and adults to avail long-term protection.
Hepatitis B vaccine safety
The safety of the hepatitis B vaccine has been evaluated in the numerous clinical studies that have been performed prior to their introduction to the market. A series of solicited local and general side effects as well as non-solicited side effects were carefully monitored.
In many studies the most frequently reported local side effect was pain at the injection side and the most frequently occurring general side effect was mild and transient fatigue which lasted for more than 48 hours. The other side effects include:
- Nausea
- Rash
- Headache
- Fever
- Malaise
- Injection site reaction
- Fatigue
- Influenza like symptoms
- Dizziness
Frequently asked questions on Hepatitis Vaccine:
-
Is there a vaccine for hepatitis b?
Yes. Hepatitis B vaccines which prevent hepatitis B in both in adults and children are invented. Usually, in the high-risk adults are vaccinated with hepatitis b vaccine if they are not vaccinated for the same in their childhood. In few immunocompetent cases, booster dose may be provided.
-
How long does hepatitis b vaccine last?
Any hepatitis B vaccine protects the individual against hepatitis B virus for at least 20 years and probably for life. In few immunocompetent cases, booster dose may be administered which enhances the immunogenicity and longevity of Hepatitis B vaccine.
-
What is hepatitis b vaccine?
Hepatitis vaccination is the immunisation of individuals against a group of deadly viral diseases which affect the liver, primarily swelling it and progressing to liver cirrhosis and ultimately cancer.
-
How often do you need hepatitis b vaccine?
Usually, a single dose of hepatitis b vaccine is enough to induce enough immunity against hepatitis required for at least 20 years to a lifetime. In few immunocompetent cases, booster dose may be administered which enhances the immunogenicity and longevity of Hepatitis B vaccine.
-
Is hepatitis vaccine safe?
Yes, hepatitis vaccine is a safe and effective therapeutic commodity. Most of the persons who receive hepatitis vaccine reported no side effects at all. In case of symptom presentation, the common side effects include pain at the injection site, soreness, or redness, and fatigue, headache, which usually last 1-2 days. Irritability, crying, vomiting, diarrhoea, drowsiness and loss of appetite may be seen in healthy infants injected with hepatitis vaccine.
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PACE Hospitals
Hitech City : Beside Avasa Hotel, Pillar No. 18, Hyderabad - 500081
Madinaguda: Mythri Nagar, Beside South India Shopping, Madinaguda, Hyderabad - 500050
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