Diagnosing Vitamin B12 Deficiency: What Doctors are Missing

PACE Hospitals

Usually, the presence of a condition called macrocytic anemia is what makes doctors suspect and begin to look for vitamin B12 Deficiency.

Usually, the presence of a condition called macrocytic anemia is what makes doctors suspect and begin to look for vitamin B12 Deficiency. But macrocytic anemia is the result of years of vitamin B12 deficiency. This means that until a doctor is willing to even LOOK FOR the easily correctable problem of vitamin B 12 deficiency, a patient will have suffered for years with symptoms. This would have been prevented if they had looked for the deficiency based simply on one of the most common physical complaints that patients have- fatigue.

Fatigue is a problem that affects most of the population at one time or another, but when it becomes chronic it can seriously affect quality of life to the extent that people become disabled. While fatigue can have MANY different causes, one underappreciated cause of fatigue is Vitamin B 12 deficiency.

When doctors suspect vitamin B12 deficiency, they will often do a routine blood test that checks for a condition called macrocytic anemia. Macrocytic anemia is characterized by particularly large red blood cells that are accompanied by a decreased Number of total cells. It is often a Consequence of vitamin B12 deficiency, but can have several other causes as well. Macrocytic anemia, however, is NOT vitamin B12 deficiency, and Vitamin B 12 deficiency can exist with or without the presence of macrocytic anemia. In fact, macrocytic anemia may not occur for up to 2 years after the Start of vitamin B12 deficiency, yet the 'standard of care' that doctors use has them look for vitamin B12 deficiency ONLY if macrocytic anemia is present!

"clinical features that are associated with
vitamin B12 deficiency may indeed precede
evidence of macrocytic anemia"

How B12 Deficiency Can Impact on the Individual...

If Vitamin B 12 deficiency were a rare problem that required expensive and invasive testing in order to find, this would be a reasonable way to look for this problem. But vitamin B12 deficiency is VERY common and testing is as easy as a simple blood test done right in the same lab that tests for macrocytic anemia! In addition, just like other medical problems that are evaluated on their OWN signs and symptoms, vitamin b12 deficiency ALSOhas its OWN signs and symptoms that can be evaluated in the same way.

Vitamin B12 deficiency has a whole list of common presenting features that include:

  • Fatigue
  • Brain fog
  • Weakness
  • Depression

People who go to the doctor with conditions such as Chronic Fatigue Syndrome often have these same symptoms, yet they are almost NEVER screened for this simple vitamin deficiency. Considering that there are over a million chronic fatigue sufferers in the US alone who are not getting help for their debilitating condition, there is no way of knowing how many people are suffering unnecessarily from a simple vitamin deficiency simply because doctors are not looking for it! One vitamin B12 researcher, Ralph Carmel, MD, a doctor who IS looking for it, believes that almost 800,000 elderly people in the United States have undiagnosed vitamin B12 deficiency- and that is just in ONE high risk group.

Besides Chronic Fatigue Syndrome, the somewhat vague symptoms of vitamin B12 deficiency can mimic many other diseases as well. According to Doctors Norbert Goebels and Michael Soyka, "Vitamin B(12) deficiency has long been associated with a wide variety of hematological, neurological, and psychiatric disorders." Unfortunately, until doctors begin to look for Vitamin B12 deficiency and not macrocytic anemia, we are calling these problems things like:

  • Chronic Fatigue
  • Fibromyalgia
  • Dementia
  • Mental Illness
  • And Even Multiple Sclerosis

Many of these patients really should be diagnosed with simple vitamin B12 deficiency. Testing for vitamin B12 deficiency is the 'standard of care' for doctors ONLY in the case of macrocytic anemia EVEN when vitamin B12 deficiency is seemingly staring them right in the face. And because standard of care is a legal protection for doctors in court, most doctors are unlikely to go 'outside of the box' to try to find answers to patient problems.

Standards of care change slowly in the medical world; with clinical guidelines lagging scientific finding by years and even decades, things are not likely to change soon until people with illnesses become educated and DEMAND testing for these simple problems that can have DRAMATIC effects on their health and their quality of life. Since doctors are not likely to look for vitamin B12 deficiency, patients and their families need to.




Share on

Request an appointment

Fill in the appointment form or call us instantly to book a confirmed appointment with our super specialist at 04048486868

Appointment request - health articles

Popular Articles

PCOD and PCOS: Causes, Symptoms, Differences, Complications and Treatment
By Pace Hospitals March 6, 2025
PCOD (Polycystic Ovary Disease) or PCOS (Polycystic ovary syndrome) treatment usually starts with lifestyle changes like weight loss, diet, and exercise. Losing just 5 to 10 percent of your body weight can help regulate your menstrual cycle. 20 minutes of moderate-intensity exercise at least five days a week can help women to lose weight. Losing weight with exercise also improves ovulation and insulin levels.
home remedies for acidity, gerd or acid reflux | home remedies for gastric, heartburn and gas
By PACE Hospitals January 3, 2025
Discover effective home remedies to manage acidity, acid reflux, heartburn and gas. Explore natural ways to ease gastric discomfort and improve digestive health.
15 best natural remedies for cough | dry cough natural remedies for adults | natural cough remedies
By PACE Hospitals October 29, 2024
Find natural home remedies for cold and dry cough for adults, babies, toddlers and during pregnancy that ease discomfort. Learn about various herbals, honey, and many more for quick relief at home.
Kidney stones symptoms and causes | Kidney stones treatment in India | What causes Kidney stones
By PACE Hospitals August 9, 2024
Kidney stones are hard deposits made of minerals and salts that form inside your kidneys. Discover their symptoms, types, causes, prevention strategies, and treatment methods to manage and prevent them effectively.
Dengue Fever Symptoms, Causes, Diagnosis and Treatment
By Pace Hospitals July 20, 2024
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin two to ten days after infection. This may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash.
Piles causes | hemorrhoids causes | hemorrhoids treatment in India |  Piles treatment in India
By Pace Hospitals June 24, 2024
Explore the detailed guide on piles (hemorrhoids) including symptoms, causes, types, risk factors, and treatment options. Find the best ways to manage and treat piles.

Recent Articles

Viral Fever Symptoms, Causes, Types, Treatment & Prevention in Telugu | Viral Fever in Telugu
By PACE Hospitals October 11, 2025
వైరల్ ఫీవర్ అనేది వైరస్ వల్ల కలిగే జ్వరం. దీని లక్షణాలు, కారణాలు, రకాలు, నివారణ పద్ధతులు మరియు సమర్థవంతమైన చికిత్స వివరాలు తెలుసుకోండి.
World Thrombosis Day 13 October 2025 – Importance, Theme, History | World Thrombosis Day
By PACE Hospitals October 11, 2025
World Thrombosis Day 2025, observed on 13 October, spreads awareness about blood clot prevention, its global theme, importance, and history in promoting vascular health worldwide.
World Arthritis Day 12 October 2025 - Theme, Importance and History | World Arthritis Day​
By PACE Hospitals October 10, 2025
World Arthritis Day 2025 on 12 October raises global awareness about arthritis, its theme, causes, symptoms, and prevention, inspiring action for better joint health and pain-free living.