Diabetes Mellitus (DM), a chronic metabolic syndrome, is characterised by persistent hyperglycaemia (increase in blood glucose levels). The main types of DM are Type 1 & type 2.
In TYPE 1 Diabetes Mellitus (DM), there is an absolute deficiency of insulin production in the body due to some gene abnormality or other causes where pancreatic beta cells do not produce insulin at all. Practically reversing Type 1 DM is not feasible except for Islets transplant containing beta cells, but still, with this transplant, much work remains to be done. The only treatment for TYPE1 DM is lifelong replacement with insulin.
In TYPE 2 Diabetes Mellitus (DM), there is either or both of the two pathologies exist. Initially, the patient develops increased peripheral resistance, i.e. insulin is secreted by the pancreas in normal amounts, but it is not acting properly on receptors (Liver / Muscle), so glucose cannot enter into the cells, and it accumulates in the blood, leading to hyperglycaemia. Increased peripheral resistance is more seen in obese individuals or patients with Metabolic syndromes.
To compensate for this increased peripheral resistance, the pancreas secretes more insulin, and finally, blood sugar comes under control, which is called the honeymoon period in diabetes mellitus. With time pancreatic beta cells get exhausted, and finally, insulin production is reduced, resulting in hyperglycaemia. In some patients, both pathologies coexist, i.e. increased peripheral resistance and decreased production of insulin by the pancreas.
Reversal of Type 2 Diabetes Mellitus (DM) is possible when we target to reduce peripheral resistance to insulin at receptors before pancreatic beta cells get exhausted. Lifestyle modification is the mainstay to reduce Peripheral Resistance; sometimes, patients need drugs to reduce this insulin resistance.
Every patient's diet must be customised based on age, activities, muscle mass size and resting energy expenditure.
The goal of nutrition management of diabetes is to maintain desirable blood glucose and blood lipid level, optimal nutritional status, and reach and maintain a healthy weight.
Recommendations are 50-60% of the calories should be from carbohydrates (more from complex carbohydrates and lesser from simple ones), fat should be limited to 30% of total calories, and protein should provide 15-20% of total calories.
Food with low glycaemic index, rich in fibres like vegetables, good quality protein such as beans, lentils, fish or chicken, fresh fruits, low-fat dairy proteins and nuts are recommended.
High glycaemic index foods, such as white rice, sugar, sweets, carbonated drinks, and junk food, must be avoided.
Physical activity should be customised according to patient BMI, waist-hip ratio, lean body mass and muscle index.
30–45 minutes of moderate-intensity exercise, 5–6 days per week, is recommended.
Cardiac aerobic activity should be done along with muscle training. Daily Aerobic activity (brisk walking/ running / cycling / swimming / sports activity etc.) should weigh around 40-50% of exercise. Muscle training using weights should be done routinely, focusing on all muscle groups.
Through diet and weight loss, one can achieve normal blood glucose levels without any medication. Diet plays a pivotal role in controlling high blood glucose. As per research studies, bariatric surgery, carbohydrate restriction, and low-calorie (LC) diets have all been effective in reversing type 2 diabetes. In recent years, the LC eating pattern has gained support from the European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) for its ability to help people with diabetes achieve and maintain a healthy weight in the short term.
Yes, type 2 diabetes can be kept under remission (blood sugar levels can be in control) with no more intake of oral medication or insulin. The remission chances will be more if the patient starts losing weight (healthy weight loss) as early as the diagnosis of type 2 diabetes. Scientists believe that the development of type 2 diabetes is influenced by fat storage in the liver and pancreas, and thereby reducing body fat can help in diabetic remission.
A diet rich in minerals, fibre, and vitamins can aid in the provision of diabetic reversal, such as
Yes, walking more can aid in controlling high blood sugar levels. Aerobic exercise includes walking, especially at a brisk pace or with moderate intensity (30 to 60 minutes), have numerous positive effects on health, such as
In type 2 Diabetes, exercise leads to an increase in insulin sensitivity. As per a research study, there was no change in blood glucose concentrations in patients who were fasting, but there was a decrease in blood sugar concentrations in patients who exercised after a meal.
The reversal rate of diabetes is directly proportional to the amount of weight loss. In a study conducted on the Indian diabetic population (newly diagnosed) where all the patients were treated with a low-calorie diet (<1500 kcal/day) and one hour of brisk walking per day. 53.1% had achieved complete reversal, and 7% achieved partial reversal at three months, followed by 50 % and 25% at one year and 46.9% and 21.9% at two years, respectively.
It depends on the patient's condition and their capability to reduce body weight. There is no exact number (age or duration of diabetes) at which a diabetic patient can reverse their condition. However, studies have shown patients with 25 years of diabetic history have reversed their diabetic condition by losing weight.
Yes, a diabetic patient with HbA1c 6.5% is reversible with the aid of lifestyle modification (daily exercise and diet), considering a patient with no associated diabetic complications.
The fastest way to reverse diabetes is by following the below-mentioned:
As per a study in India, all patients with type 2 DM included in the study with associated body mass index (BMI) of less than 35 kg/m2 reversed their diabetes within three months after undergoing the Roux-en-Y Gastric Bypass procedure.
One can prevent the diabetic condition from the prediabetic stage by adhering to the following:
As per the Centers for Disease Control & Prevention (CDC) report, participants in lifestyle change programs recognised by the CDC who lost 5-7 % of their body weight and increased their weekly exercise time to 150 minutes had shown a 58% decrease in developing type 2 diabetes risk, among which 71 % are of over 60 years old.
The five rules of diabetes control are as follows:
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