List of Possible COVID-19 Vaccine Side Effects and Its Duration

PACE Hospitals

Globally people are continuously putting efforts on developing COVID-19 vaccines to overcome the pandemic situation so that people can go back to their normal life. 


Around the world, some COVID-19 vaccines such as The Pfizer/BioNtech Comirnaty - 31 December 2020, The SII/Covishield and AstraZeneca/AZD1222 - 16 February 2021, The Janssen/Ad26.COV 2.S - 12 March 2021, The Moderna (mRNA 1273) - 30 April 2021, The Sinopharm - 7 May 2021, The Sinovac-CoronaVac - 1 June 2021; was listed for WHO Emergency Use Listing (EUL) to reduce the impact and long-term complications caused by Coronavirus (SARS-CoV-2).


Emergency Use Authorization (EUA) is a mechanism that allow vaccines, drugs or medicine to use under medical counter measures during public health emergencies or a pandemic situation.

Emergency Use Authorization (EUA) of COVID-19 vaccines are sanctioned after many rigorous clinical trials, efficacy, laboratory assessments, effectiveness, risks vs benefits, safety and quality production of antibodies. 

Initially in Phase 1 clinical trial, the vaccine is given to the small number of healthy participants to understand the immune response, access safety and right amount of dosage.


To analyse safety concerns and short-term risks vs benefits, Phase 2 clinical trial include few hundreds participants with various health conditions from different demographics.


In Phase 3 clinical trial, the vaccine is given to thousands of participants in random manner to collect the critical information related to efficacy, immune response, short term effects and safety concerns. 

What are the possible side effects of COVID-19 vaccine?

After the rigorous clinical trials, safety and efficacy data, COVID-19 vaccines will be administered to the general population. As per WHO, COVID-19 vaccines are safe and effective and help people to protect from getting Coronavirus (COVID-19) infection. 


Vaccines are created to provide immunity against the life-threatening diseases. As per Ministry of Health and Family Welfare (MoHFW), Government of India, some People may develop mild to moderate side effects due to their immune response after taking vaccine, which is normal. Common mild to moderate side effects usually go away after a few days.


These are some common side effects of COVID-19 vaccine that can affect bodily functions and ability to perform activities:


  1. Redness, pain or swelling at the site of injection
  2. Body and muscle pain
  3. Dizziness 
  4. Malaise, feeling ill, uneasy or discomfort
  5. Fatigue, feeling tired
  6. Headache
  7. Fever
  8. Chills
  9. Nausea
  10. Diarrhea
Common side effects of COVID-19 vaccine | Coronavirus

How long do COVID-19 vaccine side effects last?

Usually, COVID-19 vaccine side effects last for nearly 2 to 3 days of getting the vaccine. In some people, side effects can stay for more than 3 days, due to their immune response to the vaccine antibodies.


Some people have not reported with any side effects, it’s totally normal if not having any side effects. Everyone responds differently to the vaccine.


It’s absolutely normal if anyone developed side effects. Vaccines are safe and getting vaccinated will help in protecting against developing severe COVID-19 infection further going into emergency medical situation. 


Side effects are more common after the second dose than the first dose. These side effects go away in few days. 

How long do COVID-19 vaccine side effects last | Coronavirus vaccine

What are the long-term side effects of COVID-19 vaccine?

After taking vaccine, it is advised to stay for 15 to 30 minutes at the vaccination center, so that immediate reaction can be taken into immediate medical attention.


Very rarely, some people may develop long-term side effects of COVID-19 vaccine, that includes:


  1. Persistent fever with chills
  2. Acute muscle pain
  3. Thromboembolism
  4. Deep vein thrombosis (DVT)
  5. Severe allergic reactions such as anaphylaxis


Some people reported to have long-term side effects after taking vaccine. After taking vaccine, body develop immunity against the SARS-CoV-2, its possible their immune system is compromised due to other health conditions. In this condition, they should consult their primary care physician and take the medications to overcome from the long-term side effects.


People are having doubt if they take COVID-19 vaccine might develop Coronavirus | COVID-19 infection. COVID-19 vaccines cannot make anyone sick with Coronavirus (SARS-CoV-2), its possible before or after person might have infected with coronavirus. COVID-19 vaccine take few weeks to develop antibodies in the body.


Currently, research is going on and finding more relevant data related to long-term effects of COVID-19 vaccine. Still people are not yet fully vaccinated, we will find information in near future once everyone is fully vaccinated.

Side effects of COVID-19 vaccine second dose | Coronavirus vaccine

What are the side effects of the COVID-19 vaccine second dose?

Due to aggressive vaccine administration to millions, we are understanding how the body is responding to Coronavirus | COVID-19 vaccines. The first dose teaches the body how to react against the virus.


Side effects reported in many young people than elderly old age people. Older people are less likely to develop any side effects, as per recent data.


COVID-19 vaccine second dose have stronger side effects. These are some common side effects reported after the second dose of COVID-19 vaccine:


  1. Extreme fatigue
  2. Painful arm
  3. Fever with chills
  4. Headache
  5. Diarrhoea
  6. Nausea and Vomiting


Response of immune system after second dose is more robust and side effects are more commonly seen after second dose in many people.

If you have taken COVID-19 vaccine and after leaving vaccination center developed any severe allegoric reaction, seek immediate medical attention.

After fully vaccinated, people can resume their regular activities simultaneously don’t forget to follow precautions like wearing mask, maintaining social distance and regularly wash hands using soap or sanitizer.


Vaccinated people are shown improvements in post covid symptoms. As per recent reports, long covid patients felt better after taking vaccine and saw phenomenal resolution in symptoms.


Share on

Request an appointment

Fill in the appointment form or call us instantly to book a confirmed appointment with our super specialist at 04048486868

Appointment request - health articles

Successful Laparoscopic Cholecystectomy performed for Symptomatic Cholelithiasis at PACE Hospitals
By PACE Hospitals July 29, 2025
Explore a case study of Symptomatic Cholelithiasis in a 42-year-old female, successfully managed with Laparoscopic Cholecystectomy at PACE Hospitals. Discover techniques, gallstones treatment options, and outcomes.
Colorectal Cancer Types, Symptoms, Causes & Treatment Explained in Telugu from PACE Hospitals
By PACE Hospitals July 29, 2025
కొలొరెక్టల్ క్యాన్సర్ పై అవగాహన కోసం ఈ వీడియోలో PACE Hospitals ఆంకాలజిస్టు డాక్టర్ రమేష్ పరిమి గారి నుండి లక్షణాలు, రకాలు, దశలు, పరీక్షలు & చికిత్స సమాచారం పొందండి.
PCOD Doctors & Specialists for PCOD treatment in Hyderabad, India at PACE Hospitals
By PACE Hospitals July 29, 2025
PACE Hospitals in Hyderabad offers advanced PCOD treatment by experienced PCOD doctors. Get expert care for irregular periods, acne, and fertility issues.
Scoliosis Types, Symptoms & Treatment Explained in Telugu by Dr. Sandeep Varma from PACE Hospitals
By PACE Hospitals July 28, 2025
స్కోలియోసిస్ రకాలు, లక్షణాలు, నిర్ధారణ, చికిత్సపై PACE Hospitals స్పైన్ సర్జన్ డా. యు ఎల్ సందీప్ వర్మ గారి సమగ్ర వివరణతో ఈ వీడియో ద్వారా పూర్తిస్థాయి అవగాహన పొందండి.
Successful PTCA performed for LAD Artery CTO in Triple Vessel Disease at PACE Hospitals
By PACE Hospitals July 28, 2025
Discover a successful PTCA case study at PACE Hospitals in a 57-year-old male with Triple Vessel Disease and LAD artery CTO. Learn how symptoms and cardiac function were improved.
World Oral Rehydration Solutions (ORS) Day, Theme, Importance & History | World ORS Day 2025
By PACE Hospitals July 28, 2025
Celebrate World ORS Day 2025—uncover its powerful theme, vital role in fighting dehydration, and the global impact of Oral Rehydration Solution in saving millions of lives.
Sinusitis (Sinus) doctors and Specialists in Hyderabad at PACE Hospitals
By PACE Hospitals July 28, 2025
Consult the best doctor for sinus in Hyderabad at PACE Hospitals. Expert ENT specialists offer advanced sinusitis treatment tailored to your needs.
Oral Cancer Symptoms & Treatment Explained in Telugu by Dr. Ramesh Parimi from PACE Hospitals
By PACE Hospitals July 26, 2025
PACE Hospitals ఆంకాలజిస్ట్ డాక్టర్ రమేష్ పరిమి గారు నోటి క్యాన్సర్ లక్షణాలు, దశలు, చికిత్సా మార్గాలు & నివారణపై ఈ వీడియోలో కీలకమైన సమాచారం అందిస్తున్నారు. ఆరోగ్య అవగాహన కోసం తప్పక చూడండి.
Successful Wide Local Excision of a Benign Breast Lump performed at PACE Hospitals.
By PACE Hospitals July 26, 2025
A successful case study from PACE Hospitals showcasing the removal of a Benign Breast Lump in a 70-year-old female through wide local excision, resulting in an excellent clinical outcome.
Show More